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Cryopreservation

WE ARE SPECIALISTS WITH INTERNATIONAL RECOGNITION

The Androscience Laboratory's semen bank consists of a structure aimed at freezing and storing semen, sperm or reproductive tissue, with the technology necessary to maintain the physiological characteristics of sperm for further use by the patient (therapeutic use), even in HIV-positive patients for infectious diseases.

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This feature is particularly useful in situations where the young or adult male will experience progressive loss of fertility. There are several medical situations that put men's reproductive capacity at risk, reducing their fertile potential. Often, these situations can be predicted, anticipated or even planned, in order to have the chance to guarantee the “preservation of fertility”, through cryopreservation for future use.

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These situations can be scored for the indication of sperm cryopreservation:

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CRYOPRESERVATION IN ASSISTED REPRODUCTION PROCESSES

  • Insemination with the partner's semen;

  • In vitro fertilization and gamete micromanipulation programs;

  • Pre-vasectomy;

  • Pre-microsurgery for reconstructive tissue reconstruction, vasectomy reversal and other complex reconstructive microsurgeries;

  • Surgical Collections:

  • - Microsurgical aspiration of epididymal sperm (MESA);

  • - Microsurgical sperm aspiration from the testes (TESA);

  • - Microsurgical extraction of sperm from the testes (TESE);

  • - Epididymal sperm puncture (PESA).

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THERAPEUTIC CRYOPRESERVATION OF SEMEN

  • Men with progressive and irrecoverable fall in spermatogenesis;

  • Alteration of the immune system/immunosuppressive therapies;

  • Chronic diseases that lead to deterioration of testicular function;

  • Individuals of reproductive age and with any type of cancer, who will be submitted to radiotherapy and/or chemotherapy, or to surgeries that may compromise their fertile potential;

  • Surgeries involving the retroperitoneum and retroperitoneal lymph node dissection;

  • High risk professionals;

  • Chronic exposure to drugs, endocrine disruptors and other harmful substances that progressively deteriorate testicular function;

  • Presence of genetic alterations;

  • Hypogonadotropic or hypergonadotropic hypogonadism.

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In most cases, cryopreservation techniques for sperm and testicular parenchyma are valuable resources in the preservation of male fertility and, in many cases, the only viable alternative available.

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CRYOPRESERVATION

During cryopreservation, a significant part of the sperm becomes unviable or suffers reduced motility and functional quality, reducing their fertilization potential. For this reason, the cryopreservation process adopted by Androscience consists of different steps that aim to optimize the quality of sperm and/or testicular parenchyma.

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CRYOPRESERVATION OF EJACULATED SPERMATOZOIDS (PERSONALIZED)

After semen collection, a careful and individualized analysis is performed to identify the best sample processing method for cryopreservation and the ideal number of samples to be stored. During cryopreservation, techniques that seek to preserve the functional quality of the gametes after thawing are used. Finally, a small aliquot of the sample is thawed to assess the sperm cryosurvival rate obtained.

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CRYOPRESERVATION OF EJACULATED SPERMATOZOIDS (BASIC)

After semen collection, basic seminal analysis is performed and then the sample is cryopreserved.
A small aliquot of the sample is frozen and, after 24 hours, a test is performed with the thawed sample to assess the cryosurvival rate of the sperm.

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